
Sterility at Every Step: From Preparation to Dressing Application
Maintaining a sterile field during catheter insertion is a cornerstone of patient safety. Central line-associated bloodstream infections (CLABSIs) and other catheter-related infections pose serious risks, leading to longer hospital stays, increased healthcare costs, and even life-threatening complications. Despite advances in infection prevention, infection rates remain unacceptably high in many clinical settings.1 This highlights the importance of adhering to rigorous aseptic techniques and ensuring every element—from preparation to dressing securement—contributes to reducing contamination risks.
The Role of ANTT® (Aseptic Non Touch Technique)
Aseptic Non Touch Technique (ANTT®) is a method designed to minimize the risk of contamination during invasive procedures, such as catheter insertions, and it is recommended in the Infusion Therapy Standards of Practice.2 The key principle behind ANTT is to avoid touching ‘key parts’ and ‘key sites’—those critical components and anatomical sites that, if contaminated, could introduce pathogens directly into the bloodstream.
By following ANTT, healthcare providers use a combination of sterile equipment, carefully controlled handling practices, and standardized processes to protect patients. Proper implementation of ANTT has been linked to reduced infection rates and improved patient outcomes.3 One crucial aspect of this approach is assembling a comprehensive sterile kit containing all necessary materials organized to facilitate aseptic handling, ensuring the insertion site remains free from contamination throughout the procedure.
Kit Considerations - Sterilization Challenge
Procedure kits more easily enable the aseptic approach by gathering all necessary tools and materials into a sterile package, simplifying the process and supporting adherence to protocol.4 However, not all materials sterilize equally well with traditional methods. Ethylene oxide (EtO) gas sterilization is used for 50% of medical devices and is the preferred method for dressings and catheters.5 However, EtO does have limitations. For example, EtO gas does not easily penetrate certain materials, including glass vials that may contain adhesive solutions like Mastisol®. Using the EtO method, the applicator of Mastisol is sterile, but the liquid contained within it is not. Overcoming this challenge requires innovation in sterilization technology.
Eloquest Healthcare’s Solution: E-Beam Sterilization
Eloquest Healthcare continuously seeks innovative ways to enhance clinical outcomes. As a part of this commitment, the company has recently adopted electron beam (E-beam) sterilization. This sterilization technology uses high-energy electrons to destroy microorganisms, achieving rapid and uniform sterilization. Unlike EtO, E-beam sterilization effectively penetrates most packaging materials uniformly. This includes glass vials, ensuring the entire Mastisol product is sterile without compromising its adhesive effectiveness. Additionally, E-beam sterilization is a more environmentally responsible option. It eliminates the toxic residues associated with EtO and reduces processing time, making it more efficient.6 This forward-thinking approach aligns with the increasing demands for safer, more sustainable healthcare solutions.
Why This Matters for Mastisol®
Mastisol Liquid Adhesive has been a trusted product for many years, largely due to efficacy and versatility. Notably, Mastisol has never been implicated in contamination leading to a patient infection. It is compatible with chlorhexidine gluconate (CHG) and does not diminish CHG’s antiseptic effectiveness.7 While it has always been safe for use in a sterile field, with the adoption of E-beam sterilization clinicians can be confident that the Mastisol liquid contained within the applicator vial is sterile. Mastisol packaging will now include a mark to indicate its sterility.

Conclusion
Preventing catheter-related infections requires meticulous attention to every detail of the insertion process, from hand hygiene to the dressing application. Maintaining intact dressings is essential to protecting patients and reducing healthcare-associated infections.8 Sterile, thoughtfully designed procedure kits provide the tools clinicians need to implement ANTT effectively. Mastisol, long trusted for dressing securement, now benefits from an advanced sterilization process that supports even the most stringent aseptic protocols. Together, these innovations help healthcare providers uphold the highest standards of patient care, ensuring safety and reducing the risk of infection at every step.
Eloquest Healthcare is committed to providing solutions that help improve vascular access dressing securement and decrease complications while reducing unnecessary costs. Mastisol® Liquid Adhesive is designed to enhance dressing adherence and minimize the risk of infection.
For more information about Mastisol®, please call 1‐877‐433‐7626 or complete this form.

References:
- Centers for Disease Control and Prevention. 2023 National and State Healthcare-Associated Infections Progress Report. U.S. Department of Health and Human Services, 2024, https://www.cdc.gov/healthcare-associated-infections/php/data/progress-report.html.
- Nickel B, Gorski L, Kleidon T, Kyes A, DeVries M, Keogh S, Meyer B, Sarver MJ, Crickman R, Ong J, Clare S, Hagle ME. Infusion Therapy Standards of Practice, 9th Edition. J Infus Nurs. 2024 Jan-Feb 01;47(1S Suppl 1): S1-S285. doi: 10.1097/NAN.0000000000000532
- Guerrero-Díaz AC, Rosa-Zamboni D, Martin-Martin MA, Rosas-Mateos I, Medina-Pelcastre M, Torres-García M, Laris-González A, Avilés-Robles M. Reducing CLABSI through a quality strategy for the implementation of the aseptic non-touch technique in a pediatric ward. Bol Med Hosp Infant Mex. 2024;81(3):182-190. English. doi: 10.24875/BMHIM.23000134. PMID: 38941636. https://pubmed.ncbi.nlm.nih.gov/38941636/
- Nelson, R., Angelovic, A., Nelson, S., Gleed, J., & Drews, F. (2015). An Economic Analysis of Adherence Engineering to Improve Use of Best Practices During Central Line Maintenance Procedures. Infection Control & Hospital Epidemiology, 36(5), 550-556. doi:10.1017/ice.2015.26. https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/abs/an-economic-analysis-of-adherence-engineering-to-improve-use-of-best-practices-during-central-line-maintenance-procedures/3E5E8DE753B868D45AB8C79E3F6E28B0
- Gamma Industry Processing Alliance; International Irradiation Association. A comparison of gamma, E-beam, X-ray and ethylene oxide technologies for the industrial sterilization of medical devices and healthcare products. Published August 31, 2017. Accessed May 22, 2025. https://gipalliance.net/wp-content/uploads/2013/01/GIPA-WP-GIPA-iia-Sterilization-Modalities-FINAL-Version-2017-October-308772.pdf
- E-BEAM Services. E-beam Sterilization. Updated 2023. Accessed May 21, 2025. https://ebeamservices.com/e-beam-sterilization/
- Ryder M, Duley C. Evaluation of compatibility of a gum mastic liquid adhesive and liquid adhesive remover with an alcoholic chlorhexidine gluconate skin preparation. J Infus Nurs. 2016;40(4):245–252.
- Gaskill, K, Wilder, K, Sneed, E, et al. Improving Maintenance of Central Line Dressing to Reduce Risk of Central Line-Associated Bloodstream Infections in an Acute-Care Setting. HCA Healthcare Journal of Medicine (2024) 5:5 doi: 10.36518/2689-0216.2025