Mastisol Clinical Evidence & Resources

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Clinical Evidence

Use the table below to browse our clinical evidence or sort by keyword. To access the data click the ‘View’ column.

wdt_IDCategoryAuthorKey FindingsPurposeSettingWhat was being adhered?View Data
1AdherenceMikhail et al.¹Mastisol was found to be significantly better than TOB in increasing adhesiveness.Compared Mastisol and tincture of benzoin (TOB) for their abilities to increase the adhesive power of wound closure strips.Artificial clinical setting/volunteersWound closure stripsView
2AdherenceMoy et al.²Mastisol significantly increased the adhesiveness of all wound closure tapes tested.Evaluated adhesive properties of 7 different wound closure tapes with and without Mastisol.Artificial clinical setting/volunteersWound closure tapesView
3Adherence | Patient SafetyLesesne³After 5 days, 60 (40%) patients in the TOB-treated group vs 10 (7%) in the Mastisol-treated group showed signs of loss of adhesiveness. Temporary contact dermatitis developed in 38% of the TOB-treated patients vs 0.7% of the Mastisol-treated patients. Four patients in the TOB-treated group developed superficial skin infections vs none in the Mastisol group.Compared Mastisol and TOB for adhesive properties and potential complications in a study of 300 patients with woundclosure strips.Surgical suiteWound closure stripsView
4AdherenceKatz et al.⁴Failure to coat the entire skin surface with Mastisol was detrimental to strip adherence.Investigated the optimal pattern of surgical strips needed to maximize adhesiveness.Artificial clinical setting/volunteersWound closure stripsView
5Adherence | Patient SafetyYavuzer et al.⁵Mastisol significantly increased the adherence of adhesive strips. Mastisol significantly improved the burst strength of wounds closed with adhesive strips alone.Compared burst strength of skin closure with sutures alone vs sutures with adhesive strips, with and without Mastisol.Artificial laboratory setting/cadaversWound closure stripsView
6AdherencePatel et al.⁶Pretreatment of the skin with Mastisol significantly increased the pullout force needed to dislodge the catheter for all tapes studied, either alone or with TOB pretreatment.Investigated “pullout force” needed to dislodge IV catheter secured with various tapes, both alone and with the addition of TOB or Mastisol.Artificial clinical setting/volunteersTapes attached to IV catheterView
7Patient SafetyJames et al.⁷16/~4500 cadets (0.3%) treated with TOB developed contact dermatitis severe enough to render them unfit for duty. 0/2200 (0%) cadets treated with Mastisol over 2 years developed contact dermatitis.Evaluated West Point military cadets during basic training for allergic contact dermatitis following treatment for friction blisters with TOB or Mastisol.Military clinical settingN/AView
8Patient SafetyKlein et al.⁸Clinician unable to work for 10 days while dermatitis was treated.Described severe contact allergic dermatitis in anesthesiologist exposed to tincture of benzoin.Operating roomSmall bandage with TOBView
9Patient SafetyRyder and Duley⁹No significant difference in the reduction of normal skin flora was observed on skin prepped with CHG/IPA vs skin prepped with CHG/IPA followed by Mastisol or Detachol. Use of Mastisol or Detachol did not affect the antiseptic effectiveness CHG/IPA.Evaluated compatibility of 2% clorhexidine gluconate/70% isopropyl alcohol (CHG/IPA) with Mastisol and Detachol to determine whether either product affected the antiseptic effectiveness of CHG/IPA.Laboratory setting/ volunteersN/AView
10Adherence | Patient SafetyDeneau and Craig¹⁰
Cookeville Regional Medical Center
With Mastisol use, fewer dressings were compromised prior to 7 days. | Nursing staff noted less damage to patients’ skin while productivity was maintained.Evaluated effectiveness of Mastisol for enhancing CVC dressing securement and preventing detachment.ICUCVC dressingsView
CategoryAuthorKey FindingsPurposeSettingWhat was being adhered?View Data

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  1. Mikhail GR, Selak L, Salo S. Reinforcement of surgical adhesive strips. J Dermatol Surg Oncol. 1986;12: 904-6.
  2. Moy RL, Quan MB. An evaluation of wound closure tapes. J Dermatol Surg Oncol. 1990;16:721-3.
  3. Lesesne CB. The postoperative use of wound adhesives. J Dermatol Surg Oncol. 1992;18:990.
  4. Katz KH, Desciak EB, Maloney ME. The optimal application of surgical adhesive tape strips. Dermatol Surg. 1999;25:686-8.
  5. Yavuzer R, Kelly C, Durrani N, Mittal V, Jackson IT, Remine S. Reinforcement of subcuticular continuous suture closure with surgical adhesive strips and gum mastic: is there any additional strength provided? Am J Surg. 2005;189:315-8.
  6. Patel N, Smith CE, Pinchak AC, Hancock DE. The influence of tape type and of skin preparation on the force required to dislodge angiocatheters. Can J Anaesth. 1994;41:738-41.
  7. James WD, White SW, Yanklowitz B. Allergic contact dermatitis to compound tincture of benzoin. J Am Acad Derm. 1984;11:847-50.
  8. Klein TG, Woehlck HJ, Pagel PS. Severe allergic contact dermatitis resulting from occupational exposure to tincture of benzoin aerosol spray in an anesthesiologist. J Anesth. 2009;23:292-4.
  9. Ryder M, Duley C. Evaluation of compatibility of a gum mastic liquid adhesive and liquid adhesive remover with an alcoholic chlorhexidine gluconate skin preparation. J Infusion Nursing. 2017;40:245-52.
  10. Deneau J, Craig A. Nursing survey reveals novel strategy in assisting adherence to best practices of CVC dressing management. Presented at: Institute for Healthcare Improvement National Forum; December 8-11, 2013; Orlando, FL.
  11. Pullen D. Quality Improvement Initiative to Improve Dressing Adherence Reveals Improved Dressing Adherence Observations on a Before-After Analysis. Presented at: Association for Vascular Access Annual Scientific Meeting, September 7-10, 2014; Washington DC.
  12. Niehaus S, McCord J. Improving Adhesion of Internal Jugular Dressings in the Intensive Care Unit. Presented at: Association for Vascular Access Annual Scientific Meeting, September 16-19, 2016;Orlando, FL.
  13. Browne B, Moffo H. Quality Improvement Initiative Results in Fewer Dressing Disruptions and Improved Adherence to Best Practices. Presented at: Greater Cincinnati AACN Chapter, 28th Annual Trends in Critical Care Conference, April 8, 2016; Cincinnati, OH.
  14. Bortz A, Hardinger K, Peltzer J. Impact of implementing Mastisol in central line dressing changes on central line-associated blood stream infections in progressive care units: a quality improvement project. Presented at: Magnetizing KC Symposium, February 24, 2015.
  15. Aldi R, Galvin K, Weintraub S, et al. Quality improvement initiative results in the standardization of processes for central line-associated bloodstream infection prevention and increased adherence to best practices. Presented at: AACN Horizons Conference, October 8-9, 2018; Manchester, NH.
  16. DeVries M, Sarbenoff J, Wickert M. Addressing the dressing: Improving dressing disruption in vascular access. Presented at: 43rd Annual CVAA Conference, April 25-27, 2018; Toronto, ON.
  17. DeVries M, Sarbenoff J, Wickert M, et al. Postimplementation monitoring following introduction of gum mastic liquid adhesive for vascular access dressings. Presented at: Association for Vascular Access Annual Scientific Meeting; September 15-18, 2018; Columbus, OH.
  18. DeVries M, Sarbenoff J, Scott N, et al. Improving vascular access dressing integrity without increased skincomplications. Presented at: Association for Vascular Access Scientific Meeting, October 4-7, 2019;
    Las Vegas, NV.
  19. Jameson L. From PRN to routine…a vascular access team’s journey to reducing PRN central venous catheter dressing changes by adding to the vascular access tool box. Presented at: Association for Vascular Access Annual Scientific Meeting, September 15-18, 2018; Columbus, OH.
  20. Squires EN, Bruggeman S. Use of gum mastic medical adhesive to maintain central venous access device dressing integrity. Presented at: Association for Vascular Access Scientific Meeting, October 4-7, 2019; Las Vegas, NV.
  21. Boudreaux A. Ventriculostomy Dressing Process Improvement. Presented at the National Teaching Institute & Critical Care Exposition, May, 2013; Boston, MA.